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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B3
All Species:
22.12
Human Site:
S439
Identified Species:
44.24
UniProt:
Q02153
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02153
NP_000848.1
619
70514
S439
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
S439
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Rat
Rattus norvegicus
P20595
619
70438
S439
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510819
683
77917
S462
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Chicken
Gallus gallus
XP_420376
698
78758
S521
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Frog
Xenopus laevis
NP_001085192
609
69543
K436
G
F
N
T
F
C
S
K
H
A
S
G
E
G
A
Zebra Danio
Brachydanio rerio
XP_001920263
608
69179
F433
G
I
V
G
F
N
A
F
C
S
K
H
A
S
A
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
S439
T
F
C
S
K
H
A
S
A
E
G
A
I
K
I
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
P439
E
I
C
S
R
I
T
P
M
E
V
V
S
M
L
Honey Bee
Apis mellifera
NP_001011632
603
68286
D429
A
Y
C
A
A
H
T
D
S
S
G
A
M
K
I
Nematode Worm
Caenorhab. elegans
Q6DNF4
675
76632
P468
Q
I
V
P
L
C
T
P
K
D
I
V
H
L
L
Sea Urchin
Strong. purpuratus
P16065
1125
126238
P932
A
L
S
A
A
S
T
P
I
Q
V
V
N
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
98.7
98.8
N.A.
88.2
85.8
93.6
88
87.4
24.2
63.8
32.2
20.1
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
99.3
99.5
N.A.
89.5
86.9
96.2
93.6
94
38.6
77.7
52.4
32.5
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
6.6
6.6
80
20
53.3
0
6.6
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
20
13.3
86.6
33.3
66.6
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
0
0
17
17
0
59
0
9
9
0
59
9
0
17
% A
% Cys:
0
0
67
0
0
17
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% D
% Glu:
9
0
0
0
0
0
0
0
0
59
0
0
9
0
0
% E
% Phe:
0
59
0
0
17
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
17
0
0
9
0
0
0
0
42
0
59
9
0
9
0
% G
% His:
0
0
0
0
0
59
0
0
9
0
0
9
9
0
0
% H
% Ile:
0
25
0
0
0
9
0
0
9
0
9
0
9
0
59
% I
% Lys:
0
0
0
0
50
0
0
9
9
0
9
0
0
59
0
% K
% Leu:
0
9
0
0
9
0
0
0
0
0
0
0
0
17
25
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
50
9
0
% M
% Asn:
0
0
9
0
0
9
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
0
9
0
0
0
25
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
59
0
9
9
50
9
17
9
0
9
9
0
% S
% Thr:
9
0
0
9
0
0
34
0
0
0
0
0
0
0
0
% T
% Val:
0
0
17
0
0
0
0
0
0
0
17
25
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _